SpiroKit1 pKa tunable amine
Composed of derivatives of nitrogen-containing heterocyclic compounds such as azetidine! It is possible to freely adjust the pKa.
Basic amines contained in drug discovery molecules are prone to ionization at physiological pH, leading to reduced lipophilicity, which is believed to affect membrane permeability and oral absorption. Furthermore, basic molecules can cause hERG inhibition and strongly bind to α-acidic glycoproteins, resulting in a decrease in the free drug concentration in plasma. "SpiroKit1" consists of derivatives of nitrogen-containing heterocyclic compounds such as azetidine, and by replacing these derivatives with parts of drug discovery molecules, it is possible to freely adjust the pKa. This adjustment can optimize issues related to hERG inhibition and cellular permeability. *For more details, please refer to the PDF materials or feel free to contact us.*
- Company：重松貿易 大阪本社
- Price：Other
